The objective of this study was to develop self-micro emulsifying drug delivery system (SMEDDS) to enhance the oral absorption of the poorly water-soluble drug, Efavirenz. The influence of the oil, surfactant and co-surfactant types on the drug solubility and their ratios on forming efficient and stable SMEDDS were investigated in detail. The SMEDDS were characterized by morphological observation, droplet size and zeta potential determination, freeze thawing and in vitro release study. The optimum formulation consisted of 45% Acconon MC-8 EP, 26.66% Cremophor EL and 13.33% Polyethylene glycol 400. In vitro release test showed a complete release of Efavirenz from SMEDDS in an approximately 4 h. The absorption of Efavirenz from SMEDDS showed increase in absorption compared with that of the marketed formulation. Our studies demonstrated the promising use of SMEDDS for the delivery of Efavirenz by the oral route.
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